Pharmacophoric requirements for cannabinoid side chains. Naphthoyl and naphthylmethyl substituted Δ 8 ‐tetrahydrocannabinol analogs | Zendy

Papahatjis Demetris P. | Zendy; Kourouli Therapia | Zendy; Makriyannis Alexandras | Zendy

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Pharmacophoric requirements for cannabinoid side chains. Naphthoyl and naphthylmethyl substituted Δ 8 ‐tetrahydrocannabinol analogs

Author(s) -

Papahatjis Demetris P.,

Kourouli Therapia,

Makriyannis Alexandras

Publication year - 1996

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570330304

Subject(s) - chemistry , side chain , cannabinoid , pharmacophore , stereochemistry , tetrahydrocannabinol , delta 9 tetrahydrocannabinol , combinatorial chemistry , organic chemistry , biochemistry , receptor , polymer

We have synthesized hybrids of classical cannabinoids and aminoalkylindoles by combining the dibenzopyran structure of Δ 8 ‐tetrahydrocannabinol with the ketonaphthyl or 1‐naphthylmethyl moieties found in aminoalkylindoles in order to investigate the role of the ketonaphthyl and 1‐naphthylmethyl pharmacophores in cannabimimetic activity.

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