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Pharmacophoric requirements for cannabinoid side chains. Naphthoyl and naphthylmethyl substituted Δ 8 ‐tetrahydrocannabinol analogs
Author(s) -
Papahatjis Demetris P.,
Kourouli Therapia,
Makriyannis Alexandras
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330304
Subject(s) - chemistry , side chain , cannabinoid , pharmacophore , stereochemistry , tetrahydrocannabinol , delta 9 tetrahydrocannabinol , combinatorial chemistry , organic chemistry , biochemistry , receptor , polymer
We have synthesized hybrids of classical cannabinoids and aminoalkylindoles by combining the dibenzopyran structure of Δ 8 ‐tetrahydrocannabinol with the ketonaphthyl or 1‐naphthylmethyl moieties found in aminoalkylindoles in order to investigate the role of the ketonaphthyl and 1‐naphthylmethyl pharmacophores in cannabimimetic activity.