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Friedländer reaction of 3‐acetyltropolones: Synthesis of naphthyridinyl‐ and allied heterocyclic‐substituted tropolones
Author(s) -
Piao MingZhu,
Imafuku Kimiaki
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330230
Subject(s) - chemistry , combinatorial chemistry , stereochemistry , medicinal chemistry
Five 3‐acetyltropolones reacted with 2‐amino‐3‐pyridinecarbaldehyde to afford the corresponding 3‐(1,8‐naphthyridin‐2‐yl)tropolones in excellent yields. In a similar manner, 1,6‐naphthyridin‐2‐yl‐,1,7‐naphthyridin‐2‐yl‐, 6‐pyrido[2,3‐ b ]pyrazinyl‐, and 1‐methyl‐6‐pyrazolo[5,4‐ b ]pyridyl‐substituted tropolones were prepared. Reactivities of amino‐substituted heteroarenecarbaldehydes in these reactions and properties of the products are also discussed.