Antineoplastic anthraquinones. II . Design and synthesis of 1,2‐Heteroannelated anthraquinones | Zendy

Chang Pong | Zendy; Chen ChiaFu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Antineoplastic anthraquinones. II . Design and synthesis of 1,2‐Heteroannelated anthraquinones

Author(s) -

Chang Pong,

Chen ChiaFu

Publication year - 1996

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570330227

Subject(s) - anthraquinones , chemistry , quinoxaline , imidazole , stereochemistry , cytotoxic t cell , organic chemistry , biochemistry , in vitro , biology , botany

Based on the “2‐phenyinaphthalene‐type” structural pattern hypothesis, a number of heterocycle‐fused anthraquinones were designed by taking morindaparvin‐A ( 2a ) as the lead structure. The compounds we synthesized and tested for antineoplastic activity include 1,2‐alkylenedioxyanthraquinone, naphtho [2,3‐ f ]‐quinoxaline‐7,12‐dione, anthra[1,2‐ d ]imidazole‐6,11‐dione and naphtho[2,3‐ f ]quinoxaline‐7,12‐dione derivatives. Most of the synthesized anthraquinones possessed various degrees of anticancer activity. One of these compounds, 2‐chloromethyl‐1 H ‐anthra[1,2‐ d ]imidazole‐6,11‐dione ( 4b ), exhibited cytotoxic activity against all tested human carcinoma cell lines.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research