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Novel heterocycles derived from substituted aroylthioureas: Synthesis of 3, l‐benzothiazin‐4‐ones, thieno[3,2‐ d ][1,3]thiazin‐4‐ones and 1,2,4‐thiadiazolo[2,3‐ a ][3,1]benzothiazin‐5‐ones
Author(s) -
Gütschow M.
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330225
Subject(s) - chemistry , benzothiazole , ring (chemistry) , bicyclic molecule , medicinal chemistry , organic chemistry
A series of heterocyclic aroylthioureas has been prepared and investigated as starting materials for ring closure reactions. The formation of several new 3,1‐benzothiazin‐4‐ones and thieno[3,2‐ d ][1,3]thiazin‐4‐ones ( via cyclocondensation reactions) is reported. Oxidative cyclizations were carried out to produce methyl benzothiazole‐4‐carboxylates ( via formation of an S‐C bond) as well as 1,2,4‐thiadiazolo‐[2,3‐ a ][3,1]benzothiazin‐5‐ones ( via formation of an SN bond).