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Synthesis of 3‐substituted 4,1,2‐benzothiadiazine 4,4‐dioxides and 2 or 3‐substituted 1,4‐benzothiazine 1,1‐dioxides
Author(s) -
Balbi A.,
Sottofattori E.,
Mazzei M.
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330223
Subject(s) - benzothiazine , chemistry , benzothiadiazine , triethyl orthoformate , reagent , organic chemistry , combinatorial chemistry , catalysis
The title compounds were prepared starting from the synthones 6 using two different synthetic approaches: 3‐substituted 1,4‐benzothiazine 1,1‐dioxides were synthesised by cyclisation with phosphorus oxychloride as the Vilsmeier reagent, while 4,1,2‐benzothiadiazine 4,4‐dioxides and 3‐substituted 1,4‐benzothiazine 1,1‐dioxides were obtained by direct diazotisation or by cyclisation with triethyl orthoformate.