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Two new indoloquinoline alkaloids from cryptolepis sanguinolenta : Cryptosanguinolentine and cryptotackieine
Author(s) -
Sharaf Maged H. M.,
Schiff Paul L.,
Tackie Albert N.,
Phoebe Charles H.,
Martin Gary E.
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330204
Subject(s) - quinoline , chemistry , indole test , alkaloid , stereochemistry , traditional medicine , organic chemistry , medicine
The roots of the indigenous West African shrub Cryptolepis sanguinolenta have proved to be a rich source of indoloquinoline alkaloids. To date, all of the alkaloids isolated have been analogs of indolo[3, 2‐ b ]quinoline. We now wish to report examples of two new indoloquinoline alkaloids which differ in the fusion of the indole and quinoline rings. The first, cryptosanguinolentine, is an angular indolo[3, 2‐ c ]quinoline. The second, cryptotackieine, is a linear indolo[2, 3‐ b ]quinoline system. Both of these families of alkaloids are without precedent from C. sanguinolenta . The structures of both were established through the extensive use of inverse‐detected micro nmr methods.