Preparation and regiochemical assignments of new pyrazolo[3,4‐c] [2,1]benzodiazepines | Zendy

Arranz Esther | Zendy; Díaz Juan A. | Zendy; Morante Esther | Zendy; Pérez Carmen | Zendy; Vega Salvador | Zendy

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Preparation and regiochemical assignments of new pyrazolo[3,4‐c] [2,1]benzodiazepines

Author(s) -

Arranz Esther,

Díaz Juan A.,

Morante Esther,

Pérez Carmen,

Vega Salvador

Publication year - 1996

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570330126

Subject(s) - chemistry , moiety , structural isomer , alkyl , pyrazole , catalysis , stereochemistry , medicinal chemistry , nitrogen atom , organic chemistry

The preparation of new pyrazolo[3,4‐ c ][2,1]benzothiazepines substituted at the nitrogen atoms of the pyrazole moiety is described. It was carried out by reaction of the 4,9‐dihydro‐9‐methyl‐4,10,10‐trioxo‐1(2) H ‐pyrazolo[3,4‐ c ][2,1]benzothiazepine ( 1 ) with several alkylating agents under both classical and phase‐transfer catalysis (PTC) conditions. Assignments of the N ‐alkyl regioisomers obtained were performed by study of their 1 H nmr spectra and NOE experiments.

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