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Preparation and regiochemical assignments of new pyrazolo[3,4‐c] [2,1]benzodiazepines
Author(s) -
Arranz Esther,
Díaz Juan A.,
Morante Esther,
Pérez Carmen,
Vega Salvador
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330126
Subject(s) - chemistry , moiety , structural isomer , alkyl , pyrazole , catalysis , stereochemistry , medicinal chemistry , nitrogen atom , organic chemistry
The preparation of new pyrazolo[3,4‐ c ][2,1]benzothiazepines substituted at the nitrogen atoms of the pyrazole moiety is described. It was carried out by reaction of the 4,9‐dihydro‐9‐methyl‐4,10,10‐trioxo‐1(2) H ‐pyrazolo[3,4‐ c ][2,1]benzothiazepine ( 1 ) with several alkylating agents under both classical and phase‐transfer catalysis (PTC) conditions. Assignments of the N ‐alkyl regioisomers obtained were performed by study of their 1 H nmr spectra and NOE experiments.