Premium
The synthesis of 3,4‐dihydro‐2‐methyl‐3‐oxo‐2 H ‐benzo‐1,4‐thiazine‐2‐carboxylic acids
Author(s) -
Leskovšek Cizej V.,
Urleb U.
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330117
Subject(s) - chemistry , thiazine , alkylation , hydrolysis , condensation , catalysis , lactam , medicinal chemistry , stereochemistry , organic chemistry , physics , thermodynamics
The synthesis of 3,4‐dihydro‐2‐methyl‐3‐oxo‐2 H ‐benzo‐1,4‐thiazine‐2‐carboxylic acids 4a, b, 6a ‐e is presented. After the condensation of o ‐aminothiophenols with diethyl 2‐bromo‐2‐methylmalonate in the presence of KF as a catalyst the nitrogen in the fused derivatives 3a, b , was alkylated to provide 5a‐f , the corresponding esters 3a, b, 5a‐f were hydrolysed.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom