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The synthesis of 3,4‐dihydro‐2‐methyl‐3‐oxo‐2 H ‐benzo‐1,4‐thiazine‐2‐carboxylic acids
Author(s) -
Leskovšek Cizej V.,
Urleb U.
Publication year - 1996
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570330117
Subject(s) - chemistry , thiazine , alkylation , hydrolysis , condensation , catalysis , lactam , medicinal chemistry , stereochemistry , organic chemistry , physics , thermodynamics
The synthesis of 3,4‐dihydro‐2‐methyl‐3‐oxo‐2 H ‐benzo‐1,4‐thiazine‐2‐carboxylic acids 4a, b, 6a ‐e is presented. After the condensation of o ‐aminothiophenols with diethyl 2‐bromo‐2‐methylmalonate in the presence of KF as a catalyst the nitrogen in the fused derivatives 3a, b , was alkylated to provide 5a‐f , the corresponding esters 3a, b, 5a‐f were hydrolysed.