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Synthesis of a new pyrrolo[1,3]diazepine: 4 H ‐pyrrolo[1,2‐ a ]thieno[2,3‐ e ][1,3]diazepine
Author(s) -
Daïch Abdelali,
Ohier Philippe,
Decroix Bernard
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320611
Subject(s) - diazepine , chemistry , intramolecular force , stereochemistry , d 1 , medicinal chemistry , ring (chemistry) , organic chemistry , receptor , biochemistry
Abstract The 4 H ‐pyrrolo[1,2‐ a ]thieno[2,3‐e][1,3]diazepine (20) was synthesized by the one‐pot intramolecular cyclization of the appropriate nitroaldehyde 13 . This key intermediate 13 was obtained by two pathways from methyl 3‐bromomethylthiophene‐2‐carboxylate (6).