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An approach to substituted 4‐hydroxypyran‐2‐ones
Author(s) -
Ramirez MaiLy,
Garey Donna,
Peña Michael R.
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320546
Subject(s) - chemistry , chloride , aryl , medicinal chemistry , combinatorial chemistry , organic chemistry , alkyl
We examined a method for the preparation of 4‐hydroxypyran‐2‐ones in two steps from aryl ketones and ethyl malonyl chloride (or ethyl 2‐methylmalonyl chloride). These 4‐hydroxypyran‐2‐ones are useful precursors as they may be transformed in two steps to the 2‐methoxypyran‐4‐ones, which is found in phenoxan—a naturally occurring compound discovered to have anti‐HIV activity.