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Synthesis of 1‐alkoxy‐5‐alkyluracils
Author(s) -
Kim DaeKee,
Kim Ganghyeok,
Lim Jinsoo,
Kim Key H.
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320536
Subject(s) - alkoxy group , chemistry , alkyl , medicinal chemistry , organic chemistry
1‐Alkoxy‐5‐alkyluracils 2a‐f have been prepared by the reaction of 2‐alkyl‐3‐methoxyacryloyl isocyanates 8a‐b with alkoxyamines 9a‐c followed by cyclization of the resulting N ‐alkoxy‐ N' ‐(2‐alkyl‐3‐methoxyacryloyl)ureas 10a‐f. The isocyanates 8a‐b were prepared from ethyl 2‐alkylacrylates 3a‐b in 5 steps.
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