Premium
Synthesis and in vitro anti‐human cytomegalovirus (hcmv) activity of certain alkenyl substituted cytosines and 5‐halocytosines
Author(s) -
Lewis Arthur F.,
Revankar Ganapathi R.,
Rando Robert F.
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320517
Subject(s) - chemistry , cytosine , human cytomegalovirus , in vitro , sodium salt , salt (chemistry) , guanine , medicinal chemistry , stereochemistry , dna , nucleotide , organic chemistry , biochemistry , inorganic chemistry , gene
The 1‐[(Z)‐2‐penten‐1‐yl] and 1‐(3‐methyl‐2‐buten‐1‐yl) derivatives of cytosine, 5‐bromocytosine, 5‐fluorocytosine, and 5‐iodocytosine were prepared by a reaction of the sodium salt of the requisite cytosine with (Z)‐1‐bromo‐2‐pentene and 4‐bromo‐2‐methyl‐2‐butene, respectively. The eight alkenylcytosines 5a‐5h were evaluated in cell culture for their anti‐HCMV activity. Only the derivatives of 5‐bromocytosine, 5c and 5d , showed slight activity in this assay.