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Aldol condensation of 6‐alkoxy‐2,2‐dimethylchroman‐4‐ones with substituted benzaldehydes using tetramethylorthosilicate and potassium fluoride
Author(s) -
Chambers R. J.,
Marfat A.
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320451
Subject(s) - chemistry , aldol condensation , potassium fluoride , alkoxy group , potassium , condensation , fluoride , medicinal chemistry , aldol reaction , organic chemistry , catalysis , inorganic chemistry , alkyl , thermodynamics , physics
The aldol condensation of 6‐alkoxy‐2,2‐dimethylchromanones 1 or 2 with substituted benzaldehydes in the presence of tetramethylorthosilicate and potassium fluoride affords 6‐alkoxy‐3‐benzylidene‐2,2‐dimethylchromanones 5‐10 while other conventional methods were unsuccessful.