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Preparation of 7‐ethoxy‐3‐hydroxy‐6‐methoxy‐1‐methyl‐4‐nitroisoquinoline
Author(s) -
Barton Donald L.,
Fabian Arthur C.,
Lam Margaret M.,
Sterbenz Jeffrey T.
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320450
Subject(s) - alkoxy group , chemistry , quinoline , salt (chemistry) , perchlorate , organic chemistry , medicinal chemistry , ion , alkyl
This paper reports the large scale preparation of 7‐ethoxy‐3‐hydroxy‐6‐methoxy‐1‐methyl‐4‐nitroiso‐quinoline (RWJ 19959, 2 ) from an available starting material, 4‐ethoxy‐3‐methoxyphenylacetic acid ( 9 ). Previously 2 was prepared via a perchlorate salt which was found to decompose exothermically.