Triazoles  XXXVI  . The arylation of 5‐amino‐3‐methylthio‐1 H ‐1,2,4‐triazole with activated aryl chlorides | Zendy

Trinka Péter | Zendy; Reiter József | Zendy

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Triazoles XXXVI . The arylation of 5‐amino‐3‐methylthio‐1 H ‐1,2,4‐triazole with activated aryl chlorides

Author(s) -

Trinka Péter,

Reiter József

Publication year - 1995

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570320443

Subject(s) - chemistry , aryl , chlorobenzene , nitro , high performance liquid chromatography , triazole , 1,2,4 triazole , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis , alkyl

The possibility of the arylation of 5‐amino‐3‐methylthio‐1 H ‐1,2,4‐triazole ( 1 ) with different chlorobenzenes activated by a nitro group was studied. The ratio of products obtained was determined by hplc using isolated products as standards. It was stated that from among the monoarylated products 8 , 9 and 10 obtained the main product is 8 . However, from the reaction mixtures diarylated derivatives 11 and 12 and different by products such as 15, 16, 22, 24, 25, 27, 28, 32, 36 , and 38 were also isolated.

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