Synthesis of pyrimidine analogs of 2,6‐Di‐ tert ‐butylphenol antiinflammatory agents | Zendy

Unangst Paul C. | Zendy; Connor David T. | Zendy; Kostlan Catherine R. | Zendy; Shrum Gary P. | Zendy; Miller Steven R. | Zendy; Kanter Gerald | Zendy

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Synthesis of pyrimidine analogs of 2,6‐Di‐ tert ‐butylphenol antiinflammatory agents

Author(s) -

Unangst Paul C.,

Connor David T.,

Kostlan Catherine R.,

Shrum Gary P.,

Miller Steven R.,

Kanter Gerald

Publication year - 1995

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570320417

Subject(s) - chemistry , pyrimidine , ketone , medicinal chemistry , stereochemistry , organic chemistry

The preparation of pyrimidine analogs of the 2,6‐di‐ tert ‐butylphenol antiinflammatory agents Prifelone (R‐830), Tebufelone (NE‐11740) and Ym‐13,162 is described. Grignard addition to the N ‐methoxy‐ N ‐methylamide derived from 4,6‐bis(1,1‐dimethylethyl)‐5‐hydroxy‐2‐pyrimidinecarboxylic acid yielded a series of 2‐pyrimidinyl ketones. Further elaboration of an ethyl ketone and cyclization with sodium cyanate gave a pyrimidinylimidazole.

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