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Carbolines. Part VII . Anisidines, convenient tools to synthesize hydroxy‐β‐carbolines
Author(s) -
Rocca Patrick,
Marsais Francis,
Godard Alain,
Quéguiner Guy,
Adams Luqman,
Alo Babajide
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320412
Subject(s) - chemistry , metalation , total synthesis , combinatorial chemistry , stereochemistry , organic chemistry
Abstract The paper describes a convenient synthesis of hydroxy‐β‐carbolines from commercial anisidines based on key steps such as metalation, cross‐coupling and cyclization. The first total synthesis of a major cyto‐toxic constituent of a marine bryozoan is also reported, the 8‐hydroxy‐1‐vinyl‐β‐carboline.