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Elucidation of the structure of quindolinone, a minor alkaloid of cryptolepis sanguinolenta : Submilligram 1 H‐ 13 c and 1 H‐ 15 N heteronuclear shift correlation experiments using micro inverse‐detection
Author(s) -
Crouch Ronald C.,
Davis Ann O.,
Spitzer Timothy D.,
Martin Gary E.,
Sharaf Maged M. H.,
Schiff Paul L.,
Phoebe Charles H.,
Tackie Albert N.
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320369
Subject(s) - chemistry , alkaloid , stereochemistry , crystallography
Abstract Elucidation of minor natural product structures has been significantly augmented by inverse‐detection; further improvement has been afforded by the development of micro inverse‐detection probes. We report here the elucidation of the structure of a new alkaloid, quindolinone (5 H , 10 H ‐indolo[3,2‐ b ]quinolin‐11‐one), from the West African plant Cryptolepis sanguinolenta. All nmr data for this minor, preparative hplc‐isolated alkaloid, including 1 H‐ 15 N onebond heteronuclear shift correlation (HMQC) data, were recorded on an 800 μg sample of the alkaloid dissolved in 140 μl of 100% d 6 ‐DMSO using a 400 MHz spectrometer.