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On the formation of estrone lactam esters of N , N ‐bis(2‐chloroethyl)aminocinnamic acid isomers, p‐N,N ‐bis(2‐chloroethyl)aminophenylbutyric acid and their antitumor activity
Author(s) -
Catsoulacos P.,
Pairas G.,
Papageorgiou A.
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320365
Subject(s) - chemistry , lactam , estrone , in vitro , in vivo , stereochemistry , medicinal chemistry , biochemistry , microbiology and biotechnology , hormone , biology
New estrone‐lactam esters, 17α‐aza‐D‐homo‐Δ 1,3,5(10) ‐estratrien‐3‐ol‐17‐one‐ N,N ‐bis(2‐chloroethyl)‐aminocinnamic isomers and p‐N,N ‐bis(2‐chloroethyl)aminophenylbutyrate have been synthesized and tested in P388 leukemia in vivo and P388 and L1210 leukemias in vitro. The effect of these compounds on SCE rates and on cell kinetics in cultured human lymphocytes was studied also.