A new route to 5,6‐diarylpyridazin‐3‐ones by metalation and cross‐coupling of pyridazines | Zendy

Trécourt F. | Zendy; Turck A. | Zendy; Plé N. | Zendy; Paris A. | Zendy; Quéguiner G. | Zendy

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A new route to 5,6‐diarylpyridazin‐3‐ones by metalation and cross‐coupling of pyridazines

Author(s) -

Trécourt F.,

Turck A.,

Plé N.,

Paris A.,

Quéguiner G.

Publication year - 1995

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570320364

Subject(s) - metalation , chemistry , regioselectivity , trimethylsilyl , combinatorial chemistry , stereochemistry , coupling (piping) , medicinal chemistry , organic chemistry , catalysis , mechanical engineering , engineering

Starting from 3,6‐dichloropyridazine, a new route is described to antihypertensive 5,6‐diarylpyridazin‐3‐ones. This pathway comprises the regioselective metalation followed by a substitution of the trimethylsilyl moeity. The introduction of iodine by another metalation allowed the cross coupling of arylboronic acids. The 6‐methoxy group was then cleaved to afford the pyridazinones.

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