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Synthesis of 3‐aminorhodanine derivatives as aldose reductase inhibitors
Author(s) -
Hanefeld Wolfgang,
Schlitzer Martin
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320358
Subject(s) - chemistry , aldose reductase , acylation , methylene , aldose , aldehyde reductase , aldose reductase inhibitor , stereochemistry , biochemistry , organic chemistry , enzyme , glycoside , catalysis
A number of 5‐condensated 3‐acylaminorhodanines 3 was prepared as potential inhibitors of the aldose reductase by acylation of the amino group of 3‐aminorhodanine 1 and subsequent condensation of the 5‐methylene function with appropriate aldehydes. Some of these compounds displayed interesting activity.