Premium
Synthesis of 3‐aminorhodanine derivatives as aldose reductase inhibitors
Author(s) -
Hanefeld Wolfgang,
Schlitzer Martin
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320358
Subject(s) - chemistry , aldose reductase , acylation , methylene , aldose , aldehyde reductase , aldose reductase inhibitor , stereochemistry , biochemistry , organic chemistry , enzyme , glycoside , catalysis
A number of 5‐condensated 3‐acylaminorhodanines 3 was prepared as potential inhibitors of the aldose reductase by acylation of the amino group of 3‐aminorhodanine 1 and subsequent condensation of the 5‐methylene function with appropriate aldehydes. Some of these compounds displayed interesting activity.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom