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Heterocycles from heterocycles. ‐ III[1]. 1,3,5‐trisubstituted hexahydro‐1,3,5‐triazines‐2‐ones from 1,3,5‐trisubstituted hexahydro‐1,3,5‐triazines and organic isocyanates
Author(s) -
Verardo Giancarlo,
Giumanini Angelo G.,
Gorassini Fausto,
Strazzolini Paolo,
Benetollo Franco,
Bombieri Gabriella
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320354
Subject(s) - chemistry , substituent , monomer , scrambling , molecule , computational chemistry , organic chemistry , stereochemistry , medicinal chemistry , polymer , philosophy , linguistics
1,3,5‐Triscubstituted hexahydro‐1,3,5‐trazin‐2‐ones 3 are easily obtained by the reaction of 1,3,5‐trisub‐stituted hexahydro‐1,3,5‐triazines 1 with organic isocyanates 2 . The reaction is believed to occur by the sequential addition to 2 of two molecules of the monomeric N ‐methyleneamines in thermal equilibrium with 1. Substituent scrambling at the operating temperature (120°) was negligible. The crystal structure of 1,3,5‐triphenylhexahydro‐1,3,5‐triazin‐2‐one (3a) has been determined by X‐ray diffraction methods.