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Synthesis and reactivity of 2,6‐diamino‐4‐methyl‐3‐pyridinecarbonitrile
Author(s) -
Katritzky Alan R.,
Rachwal Stanislaw,
Smith Terrance P.,
Steel Peter J.
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320351
Subject(s) - chemistry , sulfonyl , derivative (finance) , yield (engineering) , benzene , reactivity (psychology) , medicinal chemistry , chloride , tris , organic chemistry , alternative medicine , pathology , financial economics , economics , metallurgy , medicine , biochemistry , alkyl , materials science
2,6‐Dihydroxy‐4‐methyl‐3‐pyridinecarbonitrile is converted via its 2,6‐dichloro analog into the corresponding 2‐amino‐6‐chloro, 2‐chloro‐6‐amino, and 2,6‐diamino derivatives. The last reacts with benzene‐sulfonyl chloride to yield a tris‐sulfonyl derivative, the structure of which is demonstrated by X‐ray analysis.
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