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Synthesis of cyclic and acyclic nucleoside analogues having a thiophene or dihydrothiophene ring fused to the d side of an uracil
Author(s) -
Jourdan Fabrice,
Renault Jacques,
Karamat Abdesselam,
Laduríe Daniel,
Robba Max
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320347
Subject(s) - chemistry , alkylation , uracil , anomer , ring (chemistry) , thiophene , nucleoside , stereochemistry , combinatorial chemistry , organic chemistry , dna , catalysis , biochemistry
Synthesis of cyclic and acyclic nucleosides was achieved by alkylation of various new aglycones following the Vorbrüggen and Niedballa's procedure [6]. The analytical results allowed us to conclude that the alkylation occured on N1 site and led to the β anomeric form for the cyclic nucleosides.