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Synthesis of trans ‐7‐hydroxymethyl‐2‐(2‐benz[ d ]isoxazol‐3‐yl)octahydro‐2 H ‐pyrido[1,2‐ a ]pyrazine
Author(s) -
Urban Frank J.
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320330
Subject(s) - chemistry , pyrazine , hydroxymethyl , trifluoromethanesulfonate , alkylation , medicinal chemistry , stereochemistry , organic chemistry , catalysis
An efficient synthesis of trans ‐7‐hydroxymethyl‐2‐(2‐benz[ d ]isoxazol‐3‐yl)octahydro‐2 H ‐pyrido[1,2‐ a ]‐pyrazine 2 is presented which relies on the equilibration of cis ‐dimethyl piperidinedicarboxylate followed by alkylation with phthalimidoethyl triflate.