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Synthesis of 3 H ‐thieno[3,2‐ c ]‐1,2‐dithiole‐3‐thione and its reaction with n ‐butylamine
Author(s) -
Pregnolato Massimo,
Borgna Pietro,
Terreni Marco
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320328
Subject(s) - chemistry , isothiazole , medicinal chemistry , antimicrobial , butylamine , stereochemistry , organic chemistry , amine gas treating
A convenient synthesis of 3 H ‐thieno[3,2‐ c ]‐1,2‐dithiole‐3‐thione (7) is proposed. The reaction of 7 with n ‐butylamine afforded the N ‐butylthieno[3,2‐ c ]isothiazole‐3(2 H )‐thione (7a) in dynamically equilibrium [1] with its 3 H ‐thieno[3,2‐ c ]‐1,2‐dithiole‐ N ‐butyl‐3‐imino isomer 7b. Characterizations and antimicrobial activities of the synthesized products are reported.