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Abnormal ring closure and oxidation in situ of 2‐hydroxy‐5‐nitrobenzaldehyde in the hantzsch synthesis
Author(s) -
Menconi Italo,
Angeles E.,
Martínez Luisa,
Posada Maria E.,
Toscano Rubén A.,
Martínez Roberto
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320325
Subject(s) - chemistry , in situ , ring (chemistry) , closure (psychology) , combinatorial chemistry , organic chemistry , market economy , economics
The Hantzsch condensation of 2‐hydroxy‐5‐nitrobenzaldehyde, ethyl acetoacetate and ammonia gave the hitherto unknown 2‐methyl‐3‐ethoxycarbonyl‐4‐ethoxycarbonylmethyl‐6‐(2‐hydroxy‐5‐nitrophenyl)‐pyridine via an unusual condensation and oxidation in situ.