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Reaction of tetrahydrobenz[ a ]acridinones with hydroxylamine hydrochloride. VII
Author(s) -
Martínez Roberto,
Rubio Manuel F.,
Guillermo Ramírez G.,
Camacho Tomas,
Irma Linzaga E.,
Mancera Claudia
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320324
Subject(s) - chemistry , hydroxylamine hydrochloride , hydroxylamine , hydrochloride , solvent , ethanol , sodium hydroxide , organic chemistry , medicinal chemistry , nuclear chemistry
Oximation of ortho ‐substituted phenylbenz[ a ]acridinones using hydroxylamine hydrochloride, sodium hydroxide and ethanol as the solvent gave always the benzoquinacridine N ‐oxide 2 . Oximation of para ‐substituted phenylbenz[ a ]acridinones, however, gave only the corresponding oximes. The structure of all products was corroborated by ir, 1 H and 13 C‐nmr and mass spectral data. Theoretical calculations support the experimental findings.