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Synthesis of pyrido[3,4‐ d ] benzazepines
Author(s) -
Kunick Conrad,
Link Andreas
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320319
Subject(s) - chemistry , benzazepines , benzazepine , adduct , ring (chemistry) , amidine , medicinal chemistry , ammonium , stereochemistry , organic chemistry
The synthesis of some derivatives of the novel heterocyclic ring system pyrido[3,4‐ d ][1]benzazepine is reported. Thus, pyrido[3,4‐ d ][1]benzazepin‐7‐one 6 was prepared by cyclisation of the Michael adduct 5 with ammonium ferric sulfate. Reaction of 6 with phosphorus pentasulfide gave the thiolactam 7 , which after methylation and subsequent reaction with amines furnished the amidines 10 .
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