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Improved syntheses of thieno[2,3‐ b ]‐ and [3,2‐ b ]‐fused naphthyridines
Author(s) -
Björk Patrick,
Aakermann Torunn,
Hörnfeldt AnnaBritta,
Gronowitz Salo
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320310
Subject(s) - chemistry , carbamate , medicinal chemistry , stereochemistry , organic chemistry
The preparation of eight isomeric thieno[2,3‐ b ]‐ and [3,2‐ b ]‐fused naphthyridines [1] was improved through the Pd(0) catalyzed cross‐coupling of 3‐formyl‐4‐iodopyridine, 2‐formyl‐3‐iodopyridine, 3‐bromo‐4‐formylpyridine and 2‐bromo‐3‐formylpyridine with t ‐butyl N ‐(2‐trimethylstannyl‐3‐thienyl)car‐bamate and t ‐butyl N ‐(3‐trimethylstanny‐2‐thienyl)carbamate.