Premium
The reformatsky reaction of 1‐acyl‐3,5‐dimethylpyrazoles. A convenient preparation of 4‐amino‐3‐oxoalkanoic acid derivatives
Author(s) -
Kashima Choji,
Kita Isanobu,
Takahashi Katsumi,
Hosomi Akira
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320303
Subject(s) - chemistry , reformatsky reaction , organic chemistry , combinatorial chemistry , amino acid , acylation , biochemistry , catalysis
Abstract The conversion of N ‐acylpyrazoles into β‐keto esters was accomplished efficiently by the treatment with α‐bromo esters and zinc dust. Using this Reformatsky reaction of N ‐acylpyrazoles, 4‐(protected amino)‐3‐oxoalkanoic acid derivatives were conveniently prepared as the key intermediates in the synthesis of statines.