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Reaction of 4‐chloropyrimidines with alkylisothioureas
Author(s) -
Hurst Derek T.
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320254
Subject(s) - chemistry , nucleophile , nitrogen atom , nitrogen , sulfate , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis , group (periodic table)
4,6‐Dichloro‐5‐nitropyrmidine reacts with S ‐methylisothiouronium sulfate to give 1‐(4‐chloro‐5‐nitropyrimidin‐6‐yl)‐ S ‐methylisothiourea by an unusual nucleophilic attack involving an isothiouronium nitrogen atom.