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Synthesis of artificial receptors as potential candidates for recognition and binding of pterin analogs
Author(s) -
Papadopoulou Maria V.,
Goswami Shyamaprosad,
Hamilton Andrew D.
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320250
Subject(s) - chemistry , pterin , aminopterin , receptor , stereochemistry , stacking , combinatorial chemistry , molecular recognition , biochemistry , molecule , organic chemistry , enzyme , methotrexate , cofactor , immunology , biology
Open chain podands 2a‐c and macrocycles 2d‐e have been synthesized as potential candidates for 4‐aminopterin recognition and binding, featuring Hbonding characteristics and “stacking interaction” 2e. Preliminary binding studies between 6, 7 , and 8 (simpler analogs of the above 2a‐e ) as “bosts” and appropriate “guests”, showed that carbamates 2a and 2e are the most promising receptors for 4‐aminopterin binding.