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A facile synthesis of 3‐alkoxy phthalides by the palladium catalyzed carbonylative cyclization of o ‐bromobenzaldehyde
Author(s) -
Shim Sang Chul,
Lee Dong Yub,
Jiang Li Hong,
Kim Tae Jeong,
Cho SungDong
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320162
Subject(s) - chemistry , palladium , catalysis , carbonylation , alkoxy group , intramolecular force , medicinal chemistry , organic chemistry , polymer chemistry , carbon monoxide , alkyl
Abstract The palladium catalyzed carbonylative cyclization of o ‐bromobenzaldehyde 1 in alcoholic solution gave 3‐alkoxyphthalides 3a‐e in 61–85% isolated yields via intramolecular cyclization induced by the coordinated formyl group on the palladium.