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Synthesis and antibacterial activity of 7‐ethyl‐3‐methyl‐4,7‐dihydro‐4‐oxoisothiazolo[5,4‐ b ]pyridine‐5‐carboxylic acid
Author(s) -
Richardson Thomas O.,
Neale Nancy,
Carwell Natosha
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320161
Subject(s) - chemistry , nalidixic acid , pyridine , carboxylic acid , antibacterial activity , quinolone , stereochemistry , organic chemistry , medicinal chemistry , bacteria , antibiotics , biochemistry , ciprofloxacin , biology , genetics
The synthesis of the quinolone, 7‐ethyl‐3‐methyl‐4,7‐dihydro‐4‐oxoisothiazolo[5,4‐ b ]pyridine‐5‐carboxylic acid 4 was accomplished utilizing the Gould‐Jacobs dependent route. The compound had very weak in vitro activity as compared to nalidixic acid versus E. coli, P. aeruginosa, K. pnuemoniae, S. aureus and P. mirabilis.