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Preparation of n ‐butyl‐2‐(2′‐triphenylmethyltetrazol‐5‐yl)phenylborinic acid
Author(s) -
Lo Young S.,
Rossano Lucius T.,
Meloni David J.,
Moore James R.,
Lee YingChi,
Arnett John F.
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320160
Subject(s) - chemistry , yield (engineering) , losartan , impurity , combinatorial chemistry , mechanism (biology) , organic chemistry , medicinal chemistry , angiotensin ii , biochemistry , metallurgy , epistemology , materials science , receptor , philosophy
Understanding the mechanism of formation of an impurity in the key step of the synthesis of Losartan ( 1 ) helped devise a procedure to synthesize the title compound in high yield.
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