Synthesis of nevirapine and its major metabolite | Zendy

Grozinger K. G. | Zendy; Fuchs V. | Zendy; Hargrave K. D. | Zendy; Mauldin S. | Zendy; Vitous J. | Zendy; Campbell S. | Zendy; Adams J. | Zendy

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Synthesis of nevirapine and its major metabolite

Author(s) -

Grozinger K. G.,

Fuchs V.,

Hargrave K. D.,

Mauldin S.,

Vitous J.,

Campbell S.,

Adams J.

Publication year - 1995

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570320144

Subject(s) - nevirapine , chemistry , metabolite , hydroxymethyl , aldehyde , reverse transcriptase inhibitor , nucleoside , stereochemistry , reverse transcriptase , combinatorial chemistry , human immunodeficiency virus (hiv) , organic chemistry , biochemistry , virology , viral load , antiretroviral therapy , biology , rna , gene , catalysis

Several synthetic methods were developed during the process optimization for the large scale synthesis of nevirapine ( 1 ), a non‐nucleoside inhibitor of HIV‐1 Reverse Transcriptase. The synthesis of its putative major metabolite 11‐cyclopropyl‐5,11‐dihydro‐4‐hydroxymethyl‐6 H ‐[3,2‐ b :2′,3′‐ e ][1,4]diazepin‐6‐one ( 2 ) and the oxidation of 2 to the corresponding aldehyde 3 , are described.

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