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Long‐range fluorine‐proton coupling in 1,2,4‐triazole derivatives
Author(s) -
Kane John M.,
Dalton Christopher R.,
Staeger Michael A.,
Huber Edward W.
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320130
Subject(s) - chemistry , substituent , fluorine , proton , methyl group , nuclear magnetic resonance spectroscopy , fluorine 19 nmr , group (periodic table) , coupling (piping) , spectral line , proton nmr , stereochemistry , crystallography , medicinal chemistry , organic chemistry , mechanical engineering , physics , quantum mechanics , engineering , astronomy
Abstract Several 1,2,4‐triazole derivatives containing a 2‐fluorophenyl substituent at either the 3‐ or 5‐position and a methyl group at the 4‐position were synthesized. These derivatives exhibit long‐range 19 F‐ 1 H and 19 F‐ 13 C through‐space coupling in their 1 H and 13 C nmr spectra between the fluorine and the 4‐methyl group. The close spatial proximity of these nuclei was confirmed by X‐ray analysis and by fluorine irradiated proton observe ({ 19 F}‐ 1 H) NOE difference spectroscopy.