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A new synthetic approach for imidazo[1,2‐ a ]imidazoles and pyrrolo[1,2‐ a ]imidazoles
Author(s) -
Kolar Patrik,
Tišler Miha
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320123
Subject(s) - chemistry , cyanamide , ethyl cyanoacetate , condensation , reaction conditions , sequence (biology) , organic chemistry , combinatorial chemistry , malononitrile , catalysis , biochemistry , physics , thermodynamics
Substituted pyrrolo[1,2‐ a ]imidazoles and imidazo[1,2‐ a ]imidazoles are prepared in a simple one pot reaction sequence from esters of heterocyclic or aromatic α‐amino acids. The reaction involves condensation with acetoine followed by cyclization with either malonodinitrile, ethyl cyanoacetate or cyanamide.