Premium
A new synthetic approach for imidazo[1,2‐ a ]imidazoles and pyrrolo[1,2‐ a ]imidazoles
Author(s) -
Kolar Patrik,
Tišler Miha
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320123
Subject(s) - chemistry , cyanamide , ethyl cyanoacetate , condensation , reaction conditions , sequence (biology) , organic chemistry , combinatorial chemistry , malononitrile , catalysis , biochemistry , physics , thermodynamics
Substituted pyrrolo[1,2‐ a ]imidazoles and imidazo[1,2‐ a ]imidazoles are prepared in a simple one pot reaction sequence from esters of heterocyclic or aromatic α‐amino acids. The reaction involves condensation with acetoine followed by cyclization with either malonodinitrile, ethyl cyanoacetate or cyanamide.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom