The reactions of heterocyclic isothiocyanates bearing an  ortho  ester group with  N ‐nucleophiles. The scope and some limitations of the reaction | Zendy

Urleb Uroš | Zendy

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The reactions of heterocyclic isothiocyanates bearing an ortho ester group with N ‐nucleophiles. The scope and some limitations of the reaction

Author(s) -

Urleb Uroš

Publication year - 1995

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570320112

Subject(s) - chemistry , thiourea , bifunctional , nucleophile , reagent , cysteamine , steric effects , ring (chemistry) , medicinal chemistry , group (periodic table) , primary (astronomy) , organic chemistry , stereochemistry , catalysis , physics , astronomy

Heterocyclic isothiocyanates bearing an o ‐ester group were converted into thiourea derivatives 2, 5, 6, 7 , and 9 using sterically large primary amines or aminoacids, and to the fused ring systems, e.g. 12 H ‐pyrido[3′,2′:4,5]pyrimido[2,1‐ b ]benzothiazol‐12‐one ( 3 ), and 6,7‐dihydro‐9 H ‐thiazolo[3,2‐ a ]thieno[3,2‐ d ]‐pyrimidin‐9‐one ( 13 ), respectively, using bifunctional reagents such as 2‐aminothiophenol or cysteamine.

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