Chemoselective preparation of ketones by the grignard reaction of  N ‐acylpyrazoles | Zendy

Kashima Choji | Zendy; Kita Isanobu | Zendy; Takahashi Katsumi | Zendy; Hosomi Akira | Zendy

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Chemoselective preparation of ketones by the grignard reaction of N ‐acylpyrazoles

Author(s) -

Kashima Choji,

Kita Isanobu,

Takahashi Katsumi,

Hosomi Akira

Publication year - 1995

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570320104

Subject(s) - chemistry , ketone , reagent , grignard reaction , yield (engineering) , grignard reagent , organic chemistry , combinatorial chemistry , materials science , metallurgy

N ‐Acylpyrazoles afford chemoselectively the corresponding ketones in good yields by the use of equimolar amounts of Grignard reagent. In the case of an optically active N ‐acylpyrazole, optical asymmetry was retained in comparable optical yield. Ketone formation by the Grignard reactions can be regarded as an important functionalization in a synthetic loop using pyrazoles as the auxiliary compound.

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