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Synthesis of 1,3‐dihydro‐3,3‐dimethyl‐2 H ‐indol‐2‐one derivatives as possible nonsteroidal cardiotonics
Author(s) -
Lee AnRong,
Huang WenHsin,
Lin TungLiang,
Shih KunMin,
Lee HsiaoFeng,
Lin ChengI
Publication year - 1995
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570320101
Subject(s) - chemistry , acetamide , nonsteroidal , inotrope , stereochemistry , organic chemistry , pharmacology , medicine
New substituted 1,3‐dihydro‐3,3‐dimethyl‐2 H ‐indol‐2‐one derivatives 19–29 and 34–43 were synthesized and examined for their inotropic activity in isolated dog ventricular tissues. Among them, compound 26 (2‐(2,3‐dimethoxybenzylamino)‐ N ‐(3,3,7‐trimethyl‐2‐oxo‐2,3‐dihydro‐1 H ‐indol‐5‐yl)acetamide) showed very potent activity.