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Formation of isoindoline derivatives from o ‐bromoacetylbenzophenones
Author(s) -
Nan'Ya Seiko,
Ishida Hirofumi,
Butsugan Yasuo
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310677
Subject(s) - chemistry , methylamine , isoindoline , ammonia , aqueous solution , medicinal chemistry , organic chemistry
o ‐Dibromoacetylbenzophenone, 2 or o ‐bromoacetylbenzophenone 3 reacted with aqueous ammonia to produce 3‐phenylisoindolin‐1‐one 5. The reaction of 3 with methylamine afforded 3‐hydroxy‐2‐methyl‐3‐phenyl‐isoindolin‐1‐one 4 and 2‐methyl‐3‐phenylisoindolin‐1‐one 5. Whereas from 2 with methylamine only 5 was obtained.