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Synthesis of oxazolo[4,5‐ c ]quinolones by thermolytic degradation of 4‐azido‐2(1 H )‐quinolones
Author(s) -
Steinschifter Waltraud,
Fiala Werner,
Stadlbauer Wolfgang
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310662
Subject(s) - chemistry , yield (engineering) , ring (chemistry) , degradation (telecommunications) , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , telecommunications , materials science , computer science , metallurgy
4‐Azido‐2(1 H )‐quinolones 1 are thermolyzed in the presence of carboxylic acids and polyphosphoric acid to yield oxazolo[4,5‐ c ]quinolones 3. Formation of other possible isomeric ring closure products such as oxazolo[5,4‐ c ]quinolones 2 or isoxazolo[4,3‐ c ]quinolones 4 could be excluded by independent syntheses.