Premium
Synthesis of 1,4‐dihydro‐4‐oxopyridazino[1,6‐ a ]indole‐3‐carboxylic acids and 1,4‐dihydro‐4‐oxopyrido[3′,2′:4,5]pyrrolo[1,2‐ b ]‐pyridazine‐3‐carboxylic acids as potential antibacterial agents
Author(s) -
Ruxer J. M.,
Lachoux C.,
Ousset J. B.,
Torregrosa J. L.,
Mattioda G.
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310648
Subject(s) - chemistry , pyridazine , indole test , carboxylic acid , nalidixic acid , stereochemistry , antibacterial activity , antibiotics , organic chemistry , bacteria , biochemistry , ciprofloxacin , biology , genetics
A few aza analogues of the quinolones have been prepared in the two families of the 1,4‐dihydro‐4‐oxopyridazino[1,6‐ a ]indole‐3‐carboxylic acids and the 1,4‐dihydro‐4‐oxopyrido[3′,2′:4,5]pyrrolo[1,2‐ b ]‐pyridazine‐3‐carboxylic acids to check their antibacterial potential. One compound 6c shows antibacterial activities of the level of nalidixic acid and represents a new lead structure differing from the classical quinolones.