Synthesis of 1,4‐dihydro‐4‐oxopyridazino[1,6‐ a ]indole‐3‐carboxylic acids and 1,4‐dihydro‐4‐oxopyrido[3′,2′:4,5]pyrrolo[1,2‐ b ]‐pyridazine‐3‐carboxylic acids as potential antibacterial agents | Zendy

Ruxer J. M. | Zendy; Lachoux C. | Zendy; Ousset J. B. | Zendy; Torregrosa J. L. | Zendy; Mattioda G. | Zendy

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Synthesis of 1,4‐dihydro‐4‐oxopyridazino[1,6‐ a ]indole‐3‐carboxylic acids and 1,4‐dihydro‐4‐oxopyrido[3′,2′:4,5]pyrrolo[1,2‐ b ]‐pyridazine‐3‐carboxylic acids as potential antibacterial agents

Author(s) -

Ruxer J. M.,

Lachoux C.,

Ousset J. B.,

Torregrosa J. L.,

Mattioda G.

Publication year - 1994

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570310648

Subject(s) - chemistry , pyridazine , indole test , carboxylic acid , nalidixic acid , stereochemistry , antibacterial activity , antibiotics , organic chemistry , bacteria , biochemistry , ciprofloxacin , biology , genetics

A few aza analogues of the quinolones have been prepared in the two families of the 1,4‐dihydro‐4‐oxopyridazino[1,6‐ a ]indole‐3‐carboxylic acids and the 1,4‐dihydro‐4‐oxopyrido[3′,2′:4,5]pyrrolo[1,2‐ b ]‐pyridazine‐3‐carboxylic acids to check their antibacterial potential. One compound 6c shows antibacterial activities of the level of nalidixic acid and represents a new lead structure differing from the classical quinolones.

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