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Synthesis of 3‐[[(2‐benzimidazolyl)thio]methyl]‐1‐methyl‐1,8‐dihydrocycloheptapyrazol‐8‐ones
Author(s) -
Kugishima Hideki,
Horie Takahisa,
Imafuku Kimiaki
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310647
Subject(s) - chemistry , thio , tropolone , methylhydrazine , medicinal chemistry , stereochemistry , organic chemistry , phenylhydrazine
3‐(Bromoacetyl)tropolone was reacted with five 2‐mercaptobenzimidazoles to give 3‐[[(2‐benzimidazolyl)thio]acetyl]tropolones. These products were heated with methylhydrazine to afford 3‐[[(2‐benzimidazolyl)thio]methyl]‐1‐methyl‐1,8‐dihydrocycloheptapyrazol‐8‐ones. In these reactions, 1‐methyl‐3‐[(1‐methylhydrazino)methyl]‐1,8‐dihydrocycloheptapyrazol‐8‐one was isolated as a minor product.