Premium
Reactions of 2,3‐dihydro‐1 H ‐cyclohepta[ b ]pyrazines with acyl halides
Author(s) -
Kawamata Yuuki,
Imafuku Kimiaki,
Li DongHao,
Jin ZhongTian,
Li ZhiHong,
Xiao YanWen
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310646
Subject(s) - chemistry , pyrazine , ring (chemistry) , tropone , medicinal chemistry , benzoyl chloride , halide , chloride , acylation , acetyl chloride , acyl chloride , friedel–crafts reaction , stereochemistry , organic chemistry , catalysis
2 When3‐dihydro‐1 H ‐cyclohepta[ b ]pyrazine ( 3 ) was treated with acetyl chloride under the Friedel‐Crafts conditions, its pyrazine ring opened to afford 2‐[ N '‐acetyl‐(2‐aminoethyl)amino]tropone. Reactions with propionyl and butyryl chloride also gave similarly ring‐opened products. On the other hand, aromatic benzoyl chlorides reacted with compound 3 to afford N ‐benzoyl‐substituted 2,3‐dihydro‐1 H ‐cyclohepta[ b ]pyrazines, in addition to ring‐opened compounds.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom