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Aminothiazole derivatives. II . A facile synthesis of condensed 4‐aminothiazole derivatives using α‐bromolactams and thioamides
Author(s) -
Uchikawa Osamu,
Aono Tetsuya
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310645
Subject(s) - thioamide , chemistry , benzazepines , derivative (finance) , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , financial economics , economics
The reaction of an α‐bromolactam with a thioamide was found to give a cyclic 4‐aminothiazole derivative. Novel heterocyclic compounds such as 4,5,6,7‐tetrahydrothiazolo[4,5‐ b ]pyridines 10 , 5,6,7,8‐tetrahydro‐4 H ‐thiazolo[4,5‐ b ]azepines 11 , 4,5,6,7,8,9‐hexahydrothiazolo[4,5‐ b ]azocine 12 and 9,10‐dihydro‐4 H ‐thiazolo[4,5‐ b ][1]benzazepines 18 were thus prepared and the utility of this method in the construction of 4‐aminothiazole‐containing compounds was suggested.