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Synthesis of N ‐alkoxycarbonyl and N ‐carboxamide derivatives of anti‐inflammatory oxindoles
Author(s) -
Robinson Ralph P.,
Donahue Kathleen M.
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310644
Subject(s) - chemistry , carboxamide , ring (chemistry) , prodrug , isocyanate , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , biochemistry , polyurethane
The synthesis of N ‐alkoxycarbonyl and N ‐carboxamide derivatives of anti‐inflammatory oxindoles is described. These compounds, sought as potential prodrugs of the parent anti‐inflammatory agents, were obtained by ring opening of the oxadiazine dione intermediates formed by the treatment of 1‐unsubstituted 3‐acyloxindoles with chlorocarbonyl isocyanate.