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A new route to arglecin by metalation and cross coupling of pyrazines. Metalation of diazines. XII
Author(s) -
Turck A.,
Plé N.,
Dog D.,
Harmoy C.,
Quéguiner G.
Publication year - 1994
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570310627
Subject(s) - metalation , chemistry , coupling reaction , alcohol , organic chemistry , catalysis , coupling (piping) , propargyl alcohol , combinatorial chemistry , mechanical engineering , engineering
The metalation of dihalogeno and halogenomethoxypyrazines was performed. The resulting pyrazines were submitted to a cross‐coupling reaction with propargyl alcohol followed, after dehydration, by a catalytic reduction. This gives a new route to the synthesis of a key intermediate in the synthesis of arglecin.